Product Information

Product nameEflornithine HCl
Cas NO68278-23-9
Molecular Weight218.629
Molecular formulaC6H13ClF2N2O2
Therap.Cat : Eflornithine Hydrochloride is an inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway.
Eflornithine Hydrochloride is the hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells.